教育经历
- 2004-2012，中国科学院大学，中科院遗传与发育生物学研究所，发育生物学（硕博连读），博士
工作经历
- 2012-2015，中国农科院植物保护研究所，博士后
- 2015-2019，俄亥俄州立大学，博士后
- 2019-至今，taptap点点投注，taptap点点app官方网站，长聘教轨副教授
研究内容
- 水稻是我国主粮作物，病害严重影响水稻产量及品质。研究水稻的抗病机理，对于保障我们国家的粮食安全意义重大。植物利用其两层先天免疫系统抵抗病原菌的侵染，植物质膜表面模式识别受体（PRR）感知病原菌相关分子模式（PAMP），激活分子模式触发免疫（PTI），而胞内受体感知效应子激活效应子触发免疫（ETI）。免疫反应的持续激活或者过度激活对植物生长不利，会导致植物自身免疫的发生，不利于作物产量提高。免疫调控机制将植物的免疫反应限制在合适的时间、合适的地点以及恰当的水平。我们的主要课题包括：1. 水稻先天免疫活性氧爆发的控制基因OsRbohI的鉴定及其调控机制；2. 水稻类病斑突变体的鉴定及其调控水稻免疫的机制；3. 水稻免疫受体SDS2的稳态调控；4. 水稻组织特异免疫的机制。
承担项目
- 1. 国家自然科学基金面上项目，项目名称：植物细胞因子VEIN调控水稻维管束免疫的分子机制，项目号：32570326，主持。（2026.1-2029.12）
- 2. 国家自然科学基金面上项目，项目名称：蛋白磷酸酶负调控水稻活性氧爆发的分子机制，项目号：32370314，主持。（2024.1-2027.12）
- 3. 国家重点研发子课题，项目名称：玉米叶斑病免疫诱抗增强技术研发（2023YFD1400103），主持。（2023.12-2027.12）
- 4. 西南作物基因资源发掘与利用国家重点实验室开放基金重点项目，项目名称：蛋白激酶 OsIPK1 调控水稻免疫的分子机制，项目号：SKL-KF202415，主持。（2024.12-2026.12）
- 5. 上海市自然科学基金面上项目，项目名称：水稻受体激酶SDS2介导的先天免疫反应负调控因子的鉴定和功能分析，项目号：21ZR1429300，主持。（2021.07-2024.06）
- 6. 上海市现代种业协同创新中心培育项目，项目名称：水稻NADPH氧化酶OsRbohB去磷酸化调控蛋白因子的鉴定和功能分析，项目号：ZXWH2150201/01，主持。（2022.01-2024.12）
- 7. taptap点点投注农工交叉（Agri-X）项目，项目名称：通过检测特征性挥发物实现对温室蔬菜病虫害的早期精准预警，项目号：AF1500088/002，主持。（2020.01-2022.12）
- 8. taptap点点投注-希伯来大学学术交流基金，项目名称：Mutagenesis induced by plant immunity in fungal pathogens，主持。（2024.5-2025.4）
论文
- (# first author, * corresponding author)
- Zheng X.#, Zhao Z., Xu Y., Bai L., Lang M., Shan W., Wang Y., Wang Z., Deng Y., Qiu S., Gao H., Wan B., Kang H., Qian Y., Chen G., Wang G.L., Fan J.* (2026). A conserved phospho-switch controls receptor kinase SDS2 activation and homeostasis in rice immunity. Science Advances. 24;12(30): aed5028
- Wang J., Wang Y., Li C., Shan W., Fan J.* (2026) Cysteine-rich receptor-like kinases OsCRK19 and OsCRK22 interact with OsRbohI to modulate ROS production and disease resistance in rice. Biochem Biophys Res Commun. 1;794:153034.
- Xu, Y.#, Bai, L.#, Han, M., Li, C.*, and Fan, J.* (2025). Antagonistic Regulation of Systemin Signaling Acts on Ligands and Receptors. Mol Plant. 10.1016/j.molp.2025.10.017.
- Bai, L.#, Xu, J., Xu, Y.*, and Fan, J.* (2025). Ubiquitination of susceptibility factor drives broad-spectrum resistance. Science China Life Sciences. 10.1007/s11427-025-3040-7.
- Zhao, Z.#, Wang, Y.#, Sun, A.*, and Fan, J.* (2025). Histone variant H2A.Z is a conserved regulator of RBOH expression and ROS production during innate immunity in Arabidopsis thaliana and Solanum lycopersicum. Biochem Biophys Res Commun 757, 151618. 10.1016/j.bbrc.2025.151618.
- Wang, J. #, Bai, L., Xu, Y., Zheng, X., Shan, W., Shi, X., Ma, S., and Fan, J.* (2025). Receptor-like cytoplasmic kinases mediated signaling in plant immunity: convergence and divergence. Stress Biol 5, 43. 10.1007/s44154-025-00219-8.
- Zhao, Z. #, Sun, A. #, Shan, W., Zheng, X., Wang, Y., Bai, L., Xu, Y., An, Z., Wang, X., Wang, Y., and Fan, J.* (2024). OsRbohI is the indispensable NADPH oxidase for molecular-patterns-induced reactive oxygen species production in rice. Plant Commun 5, 101129. 10.1016/j.xplc.2024.101129.
- Wang, G. #, Zhao, Z., Zheng, X., Shan, W., and Fan, J.* (2022). How a single receptor-like kinase exerts diverse roles: lessons from FERONIA. Mol Hortic 2, 25. 10.1186/s43897-022-00046-9.
- Wang, Y. #, An, Z., Zhao, Z., Li, C.*, and Fan, J.* (2022). Real-Time Detection of Reactive Oxygen Species Production in Immune Response in Rice with a Chemiluminescence Assay. J Vis Exp. 10.3791/64776.
- Zhao, Z. #, Fan, J. #, Gao, Y.G., Wang, Z., Yang, P., Liang, Y., Opiyo, S., and Xia, Y.* (2022). Arabidopsis Plasma Membrane ATPase AHA5 Is Negatively Involved in PAMP-Triggered Immunity. Int J Mol Sci 23. 10.3390/ijms23073857.
- Fan, J. #, Xia, Y.*, and Wang, G.L.* (2019). An improved heteroduplex analysis for rapid genotyping of SNPs and single base pair indels. Biotechniques 67, 6–10. 10.2144/btn-2019-0012.
- Fan, J. #, Bai, P., Ning, Y., Wang, J., Shi, X., Xiong, Y., Zhang, K., He, F., Zhang, C., Wang, R., Meng, X., Zhou, J., Wang, M., Shirsekar, G., Park, C.H., Bellizzi, M., Liu, W., Jeon, J.S., Xia, Y., Shan, L., Wang, G.L.* (2018). The Monocot-Specific Receptor-like Kinase SDS2 Controls Cell Death and Immunity in Rice. Cell Host Microbe 23, 498–510.e495. 10.1016/j.chom.2018.03.003.
- Liu, W#., Fan, J.#, Li, J., Song, Y., Li, Q., Zhang, Y., and Xue, Y.* (2014). SCFSLF-mediated cytosolic degradation of S-RNase is required for cross-pollen compatibility in S-RNase-based self-incompatibility in Petunia hybrida. Front Genet 5, 228. 10.3389/fgene.2014.00228.
- Yang, R. #, Shi, Q. #, Huang, T., Yan, Y., Li, S., Fang, Y., Li, Y., Liu, L., Liu, L., Wang, X., Peng, Y., Fan, J., Zou, L.*, Lin, S., Chen, G.* (2023). The natural pyrazolotriazine pseudoiodinine from Pseudomonas mosselii 923 inhibits plant bacterial and fungal pathogens. Nat Commun 14, 734. 10.1038/s41467-023-36433-z.
- Yang, P. #, Zhao, Z., Fan, J., Liang, Y., Bernier, M.C., Gao, Y., Zhao, L., Opiyo, S.O., and Xia, Y.* (2023). Bacillus proteolyticus OSUB18 triggers induced systemic resistance against bacterial and fungal pathogens in Arabidopsis. Front Plant Sci 14, 1078100. 10.3389/fpls.2023.1078100.
- Zhao, Z. #, Fan, J., Yang, P., Wang, Z., Opiyo, S.O., Mackey, D., and Xia, Y.* (2022). Involvement of Arabidopsis Acyl Carrier Protein 1 in PAMP-Triggered Immunity. Mol Plant Microbe Interact 35, 681–693. 10.1094/mpmi-02-22-0049-r.
- Zhang, C. #, Fang, H., Shi, X., He, F., Wang, R., Fan, J., Bai, P., Wang, J., Park, C.H., Bellizzi, M., Zhou, X., Wang, G.L.*, Ning, Y.* (2020). A fungal effector and a rice NLR protein have antagonistic effects on a Bowman-Birk trypsin inhibitor. Plant Biotechnol J 18, 2354–2363. 10.1111/pbi.13400.
- Zhao, Z. #, Yang, X., Lü, S., Fan, J., Opiyo, S., Yang, P., Mangold, J., Mackey, D., and Xia, Y.* (2020). Deciphering the Novel Role of AtMIN7 in Cuticle Formation and Defense against the Bacterial Pathogen Infection. Int J Mol Sci 21. 10.3390/ijms21155547.
- Wang, J. #, Wang, S., Hu, K., Yang, J., Xin, X., Zhou, W., Fan, J., Cui, F., Mou, B., Zhang, S., Wang, G.L., Sun, W.* (2018). The Kinase OsCPK4 Regulates a Buffering Mechanism That Fine-Tunes Innate Immunity. Plant Physiol 176, 1835–1849. 10.1104/pp.17.01024.
- Zhao, H. #, Wang, X.#, Jia, Y.*, Minkenberg, B., Wheatley, M., Fan, J., Jia, M.H., Famoso, A., Edwards, J.D., Wamishe, Y., Valent, B., Wang, G.L., Yang, Y. (2018). The rice blast resistance gene Ptr encodes an atypical protein required for broad-spectrum disease resistance. Nat Commun 9, 2039. 10.1038/s41467-018-04369-4.
- Li, J. #, Zhang, Y., Song, Y., Zhang, H., Fan, J., Li, Q., Zhang, D., and Xue, Y.* (2017). Electrostatic potentials of the S-locus F-box proteins contribute to the pollen S specificity in self-incompatibility in Petunia hybrida. Plant J 89, 45–57. 10.1111/tpj.13318.
- Wang, R.,# Ning, Y.#, Shi, X., He, F., Zhang, C., Fan, J., Jiang, N., Zhang, Y., Zhang, T., Hu, Y., Bellizzi, M., Wang, G.L.* (2016). Immunity to Rice Blast Disease by Suppression of Effector-Triggered Necrosis. Curr Biol 26, 2399–2411. 10.1016/j.cub.2016.06.072.
- Shirsekar, G.S.#, Vega-Sanchez, M.E., Bordeos, A., Baraoidan, M., Swisshelm, A., Fan, J., Park, C.H., Leung, H., and Wang, G.L.* (2014). Identification and characterization of suppressor mutants of spl11- mediated cell death in rice. Mol Plant Microbe Interact 27, 528–536. 10.1094/mpmi-08-13-0259-r.
- Ning, Y.#, Shi, X.#, Wang, R.#, Fan, J., Park, C.H., Zhang, C., Zhang, T., Ouyang, X., Li, S., and Wang, G.L.* (2015). OsELF3-2, an Ortholog of Arabidopsis ELF3, Interacts with the E3 Ligase APIP6 and Negatively Regulates Immunity against Magnaporthe oryzae in Rice. Mol Plant 8, 1679–1682. 10.1016/j.molp.2015.08.004.
专利著作
- 范江波、赵智芳、孙爱清、单文峰，OsRbohI基因在调控水稻抗病性中的应用
- 范江波、郑馨航、赵智芳、李璨、宋士任，一种水稻SIPP1基因在调控水稻对稻瘟病的抗性中的应用
- 范江波、单文峰、王志远、宋士任、李璨，OsCPK8基因在调控水稻抗病性中的应用
- 范江波、郑馨航、赵智芳、宋士任、李璨, SIPP2基因在提高水稻稻瘟病抗性中的应用
- 范江波、王英、郑馨航、宋士任、李璨, RIRE基因在提高水稻抗稻瘟病能力中的应用
- 范江波、王英、郑馨航、宋士任、李璨，水稻ATL119基因和水稻ATL120基因在调控稻瘟病抗性中的应用